Cart
sales@molnova.com
TCO-NHS ester
CAS No. 1191901-33-3
TCO-NHS ester( —— )
Catalog No. M33512 CAS No. 1191901-33-3
TCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 79 | Get Quote |
|
| 5MG | 112 | Get Quote |
|
| 10MG | 164 | Get Quote |
|
| 25MG | 266 | Get Quote |
|
| 50MG | 420 | Get Quote |
|
| 100MG | 605 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
-
Product NameTCO-NHS ester
-
NoteResearch use only, not for human use.
-
Brief DescriptionTCO-NHS ester is a alkyl/ether-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules.
-
DescriptionTCO-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
-
In VitroPROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
-
In Vivo——
-
Synonyms——
-
PathwayPROTACs
-
TargetPROTAC
-
RecptorPROTAC Linker
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1191901-33-3
-
Formula Weight267.28
-
Molecular FormulaC13H17NO5
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 100 mg/mL (374.14 mM; Ultrasonic )
-
SMILESO=C(OC1CCCC=CCC1)ON1C(=O)CCC1=O
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562?
molnova catalog
related products
-
Boc-Val-Cit-PAB-PNP
Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
-
BETd-260
BETd-260 (ZBC260, BETd260) is a novel PROTAC BET degrader that tether HJB97 to a ligand for the E3 ubiquitin ligase VHL.
-
Bromo-PEG3-C2-acid
Bromo-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
